Children's environments, experiences, and relationships drive how they learn and develop--more so than their genes. This article discusses how education leaders can help transform the antiquated U.S. education system into one that drives toward equity and prepares all students for thriving in school and in life. Informed by recent advances in the science of learning and development and building on years of practice knowledge and experience, schools can be designed to foster the holistic development of engaged, self-directed learners who have the knowledge, competencies, and higher order skills they need for success in a changing world.