This study explored how teachers' working conditions or school context variables (job demands and job resources) were related to their teaching self-concept, teacher burnout, job satisfaction, and motivation to leave the teaching profession among teachers in Norwegian senior high school. Participants were 546 teachers in three counties in central Norway. We analyzed data by means of confirmatory factor analyses and SEM analysis for latent traits. The results supported expectations derived from the Job Demands-Resources model of one health impairment process and one motivational process, but also showed that these processes are related. The analyses indicated that, in the teaching profession, different dimensions of job demands and job resources predict teachers' well-being and motivation differently.