This study addressed predictors of pre-service teachers' opposition toward the practice of educating students with disabilities in mainstream classroom settings--a practice known as inclusion. We tested a hypothesized path model that incorporated social dominance orientation (SDO) and contact as distal predictors, and intergroup anxiety, stereotype use, and self-efficacy for including students with disabilities as more proximal predictors of opposition to inclusion in a sample of 229 pre-service teachers from the Southwestern United States. In large part, the predicted relationships among our variables were supported. The effect of SDO on opposition to inclusion was both indirect (via stereotype use and intergroup anxiety) and direct. The effect of close contact with persons with disabilities relevant to inclusion was mediated by intergroup anxiety and, more distally, by stereotype use. Stereotype use and intergroup anxiety were positive predictors of opposition to inclusion. The predicted relationship between self-efficacy and opposition to inclusion was not supported by the data. Rather, the data supported a reverse causal ordering. Implications for future research are addressed.