As an instructional framework, Universal Design for Learning (UDL) can guide science teachers to purposefully apply evidence-based instructional practices to increase engagement and learning of students with disabilities (Israel, Ribuffo, and Smith 2014; Marino et al. 2014; Ok et al. 2016). This article describes how to use the Universal Design for Learning (UDL) framework to integrate strategies to reduce potential learning barriers and support the learning of students with disabilities in a 5E unit targeting the Next Generation Science Standards performance expectation 5-ESS3-1, Obtain and combine information about ways individual communities use science ideas to protect the Earth's resources and environment (NGSS Lead States 2013). In the unit, students explore how the city and community have worked together to improve the water quality and biodiversity of the Bayou Chico watershed in Pensacola, Florida, though inquiry activities, class discussions, reading and writing tasks, and a group research project.