With the increased focus on both inquiry and 21st-century skills such as collaboration and problem-solving, teachers at all levels are looking for engaging ways to create more student-centered classrooms in which students can learn more than "just" science content. Discovering and developing creative science activities designed to accomplish multiple learning objectives has become part of the must-do list for every teacher. This article shares the successes experienced in integrating the important health concept of tooth decay with data analysis. (Contains 5 figures.)