The concept of effect size plays a crucial role in assessment, institutional research, and scholarly inquiry, where it is common with large sample sizes to find small relationships that are statistically significant. This study examines the distribution of effect sizes from institutions that participated in the National Survey of Student Engagement (NSSE) and empirically derives recommendations for their interpretation. The aim is to provide guidelines for researchers, policymakers, and assessment professionals to judge the importance of an effect from student engagement results. The authors argue for the adoption of the recommendations for interpreting effect sizes from statistical comparisons of NSSE data.