Purpose: The role of rehabilitation counseling in addressing major public health issues is an emerging area in the field. Despite higher rates of disease burden among currently or formerly incarcerated people, the syndemic effects of incarceration has received little attention. This article outlines how to think of incarceration from a syndemic perspective. Method: The authors of this article draw upon syndemic theory to 1) describe the social determinants of health that lead to a greater risk of incarceration of people with substance use disorders (SUD), mental illness (MI), and infectious diseases (ID), 2) describe the syndemic impact of incarceration leading to more significant levels of disability for these populations, and 3) discuss implications for rehabilitation counseling professionals. Results: This article highlights that incarceration may interact synergistically in various syndemics, having an exacerbated health and economic effects on individuals who are/were incarcerated, their families, and communities. Conclusions: By employing stigma reduction strategies, advocating for prevention and treatment services, and addressing social determinants of health, rehabilitation counseling professionals have a substantial role to play in mitigating the syndemic impact of incarceration on people with SUD, MI, and ID.