Comprehensive, integrated, three-tiered models are context specific and developed by school-site teams according to the core values held by the school community. In this article, the authors provide a step-by-step, team-based process for designing comprehensive, integrated, three-tiered models of prevention that integrate academic, behavioral, and social domains. First, the authors discuss the importance of beginning with securing commitments and clarifying agreements. Second, they describe the core elements of a comprehensive, integrated, three-tiered plan. Then, they outline a 6-part, data-informed training series, emphasizing the importance of incorporating feedback from stakeholders to inform design through an iterative process.