This Intersegmental Data Partnerships Resource Guide, and the accompanying PACE policy brief (see ED591080), are products of a year-long qualitative research project exploring promising practices in data sharing and data use among intersegmental partnerships throughout California. This Resource Guide provides institutions engaged in intersegmental partnerships with resources to support the development, planning, and monitoring of their data practices. It is intended to serve three purposes: (1) a framework to orient intersegmental leaders to the different aspects of effective strategies for data sharing and use; (2) a tool to facilitate reflection on current regional and institutional priority areas and data practices; and (3) a networking resource to identify and learn about data practices from other partnerships in the state. The guide presents the critical components of effective regional efforts around data sharing and use, with tools to dive deeper into specific factors within each of these components. A directory of the partnerships included in the study is provided at the end of the guide.