In this keynote address presented at the 2008 National Consortium for Specialized Secondary Schools of Mathematics, Science and Technology (NCSSSMST) Professional Conference, Stephanie Marshall describes what is needed to transform STEM education in today's world. While such an endeavor will take multiple systemic actions, here Marshall focuses on three: (1) The need to transform the way mathematics and science are taught so school science and math and real science and math, are the same and not estranged; (2) The need to transform the way mathematics and science are learned so all children are immersed in the knowledge, skills and habits of mind essential for doing real science--ethical inquiry, and creative and collaborative problem-finding and solving; and (3) The need to transform this nation's system of STEM education P-20, so that innovation is ignited and sustained, and the language of mathematics and science is "spoken" and understood by all Americans. Marshall believes it will take a new map--a new design, and states that STEM leaders have significant experience with what it needs to be: (1) Concept-centered, experiential, and integrative curriculum, so children understand fundamental science concepts, deep organizing principles and linkages, and how science builds knowledge and enriches the human experience; (2) Inquiry-based, problem-centered, and technology embedded instruction, so children engage in the process of doing science, not as an experimental "recipe," but as an unfolding inquiry because real world problems are messy, complex, and tangled and science knowledge is tentative; (3) Extensive practice and immersion in self-determined and self-directed investigation and research with mentors and peer collaborative teams, in real and virtual laboratories and incubators, and in the natural world so that students are immersed in the joy of doing real science; and (4) Authentic, on-going, multi-dimensional, and performance-based assessment; so children are invited to creativity demonstrate evidence of their understanding, in multiple and novel ways. She discusses how the NCSSSMST, as a real and virtual global STEM Innovation Network, could be a dynamic force for transformation. (Contains 1 note.)