Work in the new area of Mind, Brain, and Education (MBE) raises epistemological and ethical issues. With respect to epistemology, the norms of the component disciplines must be honored and the resulting amalgam must be more than a mere sum of the parts. With respect to ethics, the roles of scientist, educator, and practitioner each raise ethical dilemmas and the MBE worker must be cognizant of each set of dilemmas and the possible strains among them. Only if both of these spheres are confronted can good work be achieved in MBE.