The "language-culture tesseract" hypothesized in the September 2010 issue of "Mind, Brain, and Education" suggests successive links between non-native language (NNL) acquisition, the development of cross-cultural empathy, and prosocial global ethics. Invoking Goethe's (1833/1999) aphorism, "those who do not know other languages know nothing of their own," it was argued that becoming plurilingual constitutes an essential step toward metalinguistic and metacultural awareness; and that "what is true of water for a fish is also true of the mother tongue and of the native culture for a human being." In this article, we would like to elaborate on that argument and submit to the MBE community the idea of applying the developing understanding of empathy in the brain toward the design of new approaches to NNL education that maximize its potential to cultivate a positive local-global dialectic in students.