One of the most important roles of a teacher is to create a safe space for learners, consistent with the Center for Applied Special Technology (CAST) Universal Design for Learning guidelines (CAST 2011). Universal Design for Learning (UDL) is a framework for teaching and learning, based on neuroscience research, that guides teachers to eliminate barriers and allows the content and curriculum to be accessible to all students (Rose et al. 2006; CAST 2017). Using the UDL framework as they plan, teachers provide students with options to stimulate and maintain their interest to learn (multiple means of engagement), present information so that students can perceive and comprehend information (multiple means of representation), and offer strategies to students to organize information and express what they know and understand (multiple means of action and expression) (CAST 2011; National Center on Universal Design for Learning [NCUDL] 2014; Novak 2016). In this article, the authors describe how teachers can use UDL in their math classroom to anticipate potential barriers, know which tools will engage students, and provide safe spaces for learning.