As crucial stakeholders in higher education, employers have long requested, demanded, and implored that colleges and universities help students develop the team skills needed to address challenges posed by innovation. Employers seek college graduates who, in the face of persistent ambiguity and within increasingly complex environments, are able to collaborate with people with a broad diversity of backgrounds, cultural origins, attitudes, beliefs, and behaviors. In this article, the authors describe the True Teamwork Model which blends concepts from psychology, anthropology, management, and philosophy. The model represents a cohesive teaching and learning strategy designed to enable students to develop teamwork skills through a three-pronged approach: (1) knowing self; (2) understanding others; and (3) collaborating to solve complex problems. The self-guided format of the model ensures that its use by students does not compete with time for in-class content delivery by faculty. The True Teamwork Model can readily be replicated or adapted to emphasize any of the three elements, and it is transferable across programs of study.