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Direct linkAmorim, Felippe E.; Chapot, Renata L.; Chapot, Renata L.; Lee, Jonathan L. C.; Amaral, Olavo B. – Learning & Memory, 2021
Remembering is not a static process: When retrieved, a memory can be destabilized and become prone to modifications. This phenomenon has been demonstrated in a number of brain regions, but the neuronal mechanisms that rule memory destabilization and its boundary conditions remain elusive. Using two distinct computational models that combine…
Descriptors: Memory, Brain Hemisphere Functions, Biochemistry, Behavior Patterns
Flavell, Charlotte R.; Gascoyne, Rebecca M.; Lee, Jonathan L. C. – Learning & Memory, 2020
The efficacy of pharmacological disruption of fear memory reconsolidation depends on several factors, including memory strength and age. We built on previous observations that systemic treatment with the nootropic nefiracetam potentiates cued fear memory destabilization to facilitate mifepristone-induced reconsolidation impairment. Here, we…
Descriptors: Fear, Drug Use, Memory, Age Differences
Cassini, Lindsey F.; Flavell, Charlotte R.; Amaral, Olavo B.; Lee, Jonathan L. C. – Learning & Memory, 2017
Retrieval of an associative memory can lead to different phenomena. Brief reexposure sessions tend to trigger reconsolidation, whereas more extended ones trigger extinction. In appetitive and fear cued Pavlovian memories, an intermediate "null point" period has been observed where neither process seems to be engaged. Here we investigated…
Descriptors: Fear, Memory, Learning Processes, Recall (Psychology)
Exton-McGuinness, Marc T. J.; Patton, Rosemary C.; Sacco, Lawrence B.; Lee, Jonathan L. C. – Learning & Memory, 2014
Once consolidated, memories are dynamic entities that go through phases of instability in order to be updated with new information, via a process of reconsolidation. The phenomenon of reconsolidation has been demonstrated in a wide variety of experimental paradigms. However, the memories underpinning instrumental behaviors are currently not…
Descriptors: Memory, Behavior, Animals, Learning
Reichelt, Amy C.; Lee, Jonathan L. C. – Learning & Memory, 2013
Despite extensive evidence that appetitive memories undergo reconsolidation, two notable failures to observe reconsolidation have been reported: instrumental responding and goal-tracking. However, these studies do not provide conclusive evidence for a lack of memory reconsolidation due to the numerous boundary conditions that dictate whether a…
Descriptors: Memory, Classical Conditioning, Goal Orientation, Learning Processes
Flavell, Charlotte R.; Lee, Jonathan L. C. – Learning & Memory, 2012
The basolateral amygdala (BLA) and the dorsal hippocampus (dHPC) are both structures with key roles in contextual fear conditioning. During fear conditioning, it is postulated that contextual representations of the environment are formed in the hippocampus, which are then associated with foot shock in the amygdala. However, it is not known to what…
Descriptors: Conditioning, Fear, Neurological Impairments, Context Effect
Theberge, Florence R. M.; Milton, Amy L.; Belin, David; Lee, Jonathan L. C.; Everitt, Barry J. – Learning & Memory, 2010
A distributed limbic-corticostriatal circuitry is implicated in cue-induced drug craving and relapse. Exposure to drug-paired cues not only precipitates relapse, but also triggers the reactivation and reconsolidation of the cue-drug memory. However, the limbic cortical-striatal circuitry underlying drug memory reconsolidation is unclear. The aim…
Descriptors: Cues, Cocaine, Symptoms (Individual Disorders), Classical Conditioning
Lee, Jonathan L. C.; Everitt, Barry J. – Learning & Memory, 2008
The theory of memory reconsolidation relates to the hypothesized restabilisation process that occurs following the reactivation of a memory through retrieval. Thus, the demonstration of reactivation-dependent amnesia for a previously acquired memory is a prerequisite for showing that such a memory undergoes reconsolidation. Here, we show that the…
Descriptors: Classical Conditioning, Recall (Psychology), Retention (Psychology), Learning Processes
Lee, Jonathan L. C.; Everitt, Barry J. – Learning & Memory, 2008
Previously acquired aversive and appetitive memories are not stable and permanent. The reactivation of such memories by re-exposure to training stimuli renders them vulnerable to disruption by amnestic agents such as the noncompetitive N-methyl-"D"-aspartate receptor antagonist (+)-5-methyl-10,11-dihydro-"SH"-dibenzo{a,d}cyclohepten-5,10imine…
Descriptors: Memory, Training, Stimuli, Physiology
Milton, Amy L.; Lee, Jonathan L. C.; Everitt, Barry J. – Learning & Memory, 2008
We have investigated the neurochemical mechanisms of memory reconsolidation and, in particular, the functional requirement for intracellular mechanisms initiated by [beta]-adrenergic signaling. We show that propranolol, given in conjunction with a memory reactivation session, can specifically disrupt the conditioned reinforcing properties of a…
Descriptors: Stimuli, Memory, Obesity, Drug Addiction
