The Latinx population continues to be underrepresented in higher education.This qualitative study explored the perceptions of 137 Latinx first-year students on factors that affected their college adjustment. Two primary domains emerged through consensual qualitative research analysis: (a) Detrimental Factors (i.e., issues that hindered adjustment) and (b) Beneficial Factors (i.e., aspects that helped adjustment).The Detrimental domain included seven categories: Academic Challenges, Poor Time Management, Cultural Difficulties, Family Problems, Financial Limitations, Health Problems, and Social Struggles. The Beneficial Factors domain included six categories:Belonging, Cultural Identity, Motivation, Perseverance, Study Skills, and Social Support.Findings demonstrate the complex factors that first-year Latinx students grapple with as they attempt to adjust to college, with the role of Latinx peers emerging as a central factor. Findings stress the need for comprehensive programs that not only attend to social, financial, and academic needs, but also address cultural factors.