The individual charged with stewarding the academic research and creative activity enterprise (i.e., Chief Research Officer or Vice President/Chancellor for Research), has tremendous responsibility and influence over the institution's ability to achieve its overall mission. Yet, the skills and knowledge required to successfully serve in this role have not been comprehensively studied. To address this deficiency, we synthesize the views of 78 sitting Chief Research Officers to document the academic and experiential pathways of respondents, their current roles and responsibilities, and future challenges. We provide recommendations for effective ways of preparing future candidates for this important role.