This study examines the reliability and validity of a Chinese-translated version of the Substance Use Risk Profile Scale (SURPS) and explores the effect of gender and age on each of the subscales. The sensitivity of SURPS in differentiating substance users and nonusers using the SURPS is also investigated. Data were collected from a convenience sample that consisted of 250 students from secondary schools in Hong Kong. Results indicated that the reliability of the subscales for introversion/hopelessness, impulsivity, sensation seeking, and anxiety sensitivity was comparable with those in previous studies. Confirmatory factor analysis supported the four-factor model of the original theoretical model of SURPS. However, no significant difference was found between each subscale score and the self-reported substance use behavior. Possible explanations on such findings are discussed. Despite the fact that the sensitivity of the SURPS in differentiating substance users and nonusers among Hong Kong adolescents is not supported, this study has provided some initial scientific evidence for adopting screening measures from the Western world to identify Chinese adolescents who are at risk for substance use. (Contains 3 tables.)