This research aims to reveal the trend in peer instruction that many researchers around the world have been working on for over 20 years. In this context, 58 papers published in journals indexed in SSCI were examined in terms of different variables (e.g., research methods, courses, and response technologies). The bibliometric results showed that the most used keyword and the most used word in the abstract sections of the studies was peer instruction. Systematic review results revealed that the continent and country with the most studies among 17 countries in four continents is North America and the USA, respectively. Moreover, the majority of studies were published in 2016. It was also found that studies are generally carried out with numerical courses such as physics, chemistry, and computer science. Other findings provided from the researches were discussed in detail, and various suggestions were made for teachers and researchers in line with the findings obtained from the study.