This study examined the effects of job design on administrative staff performance in higher education in Ghana. It further sought to establish whether the administrators' selected demographic characteristics had any relationships with main job design effects on their performances in assigned roles. Four hundred and twenty participants drawn from the administrative sections of five universities in Ghana were purposively sampled. Data were analyzed using descriptive and inferential statistics. The study identified that job design had many effects on administrative staff performance, including being able to specialize in a particular task and gain in-depth knowledge of task performance. The research also found significant associations between the staff's selected demographic characteristics and the key job design effects on staff performance.