Obesity has been increasing in all age groups worldwide for the past several decades. Yet for hundreds of years before the last quarter of the 20th century, obesity was not an issue. The etiology and the cure for the obesity epidemic have been elusive. Weight reduction diets and behavior therapy have not produced the desired results. Perhaps current obesity interventions have been focused on the wrong part of the equation. Food and nutrients contained therein may not be central in the etiology of obesity. The cause of obesity is certainly multifactorial and will require a multi-disciplinary approach to cure.