To reduce problems associated with youth substance use, Indiana developed funding streams and infrastructure to facilitate coordination of statewide prevention efforts. These prevention efforts aimed at youth include programming in the non-school hours. To examine the relationship between these efforts and youth substance abuse, students indicating participation in one or more prevention activities were compared to non-participant students. Results revealed that participating middle school students were less likely to have reported use of tobacco than their non-participating peers. Also, participation in prevention activities in the non-school hours was related to a lower likelihood of alcohol use among high school students. (Contains 3 tables.)