This paper reviews Ghana's performance in the TIMSS 2011 survey in comparison with other African and some high performing countries which participated in the TIMSS assessment. Students' achievement in the science content areas assessed were summarized and teacher preparation constructs of teachers of the students who took part in the assessment explored with the aim of finding any possible linkage between teacher preparation and students achievement. Two set of reviews were done. First, results on the eighth grade (JHS 2) science content achievement in biology, chemistry, physics, and earth science for Ghana, Morocco and Tunisia were compared. The second review compared how Ghana prepares her teachers to Finland and Singapore who were among the first five performing countries on the TIMSS 2011 assessment. Some mismatch was identified in terms of teacher preparation and students' achievement in the case of Ghana. Ghanaian teachers scored relatively high on most of the constructs that were measured by the TIMSS report under teacher preparation but these were not reflected in the students' achievement. In view of this, it is recommended that other indicators such as classroom instruction, resources for teaching science, and school climate are investigated with the aim of finding any other underlying factors that could account for the mismatch between Ghanaian students' achievement on the TIMSS science assessment and teachers' preparation.