Pregnant women and women who might become pregnant, including middle school- and high school-age adolescents, continue to consume alcohol, placing themselves at risk of having a child with the effects of prenatal alcohol exposure. However, most prevention programs that attempt to increase public awareness and knowledge of FAS and related disorders have had limited success and are inappropriate for 11 through 17-year-old youth. This study assessed the effectiveness of a pilot multimedia presentation that was implemented by peers and slightly older college students and incorporated into the middle school and high school health education programs. Posttests and follow-up assessments were compared to pretest scores to measure change in knowledge related to the effects of prenatal alcohol exposure and understanding of the overall purpose of the program. In general, students' overall knowledge of presentation content increased from pretest to posttest. Overall follow-up scores showed that students' retention of the presentation information had increased since the posttest. The findings suggest that FAS/FAE presentations led by peers and utilizing a multimedia/discussion format effectively increase middle school and high school students' knowledge of the effects of alcohol consumption during pregnancy.