The purpose of this study is to investigate the association between self-efficacy and maintenance of interest in science, technology, engineering, and mathematics (STEM) resulting in completion of an undergraduate degree in a science related area. To pursue this analysis, the researchers surveyed 3,510 graduates from selective specialized science high schools within the United States as well as 603 same age participants in Talent Search programs who did not graduate from a specialized science high school. Using binary logistic regression analysis, the researchers identified individual-level variables associated with the decision by both groups of high-ability adolescents to earn an undergraduate degree in STEM. These variables include self-efficacy and stability of interest in science, mathematics, and/or technology, and suggest that both specialized science high schools and Talent Search programs both serve equally well as incubators of talent for adolescents with a proclivity for STEM related disciplines.