The study aimed to examine the relationship between teachers' motivation and their job satisfaction. The participants of the study comprised 414 teachers selected via random cluster method from different schools in the districts of Erzurum province, east of Turkey. In the study, mixed methods was adopted based on both qualitative and quantitative data. The data were collected via the Multidimensional Work Motivation scale and the Minnesota Job Satisfaction Scale in 2019-2020 school year. The data were analyzed using descriptive statistical techniques, Pearson correlation analysis and multiple linear regression analysis. The results of the research revealed that the intrinsic motivation of teachers was higher than their extrinsic motivation, and their intrinsic satisfaction was higher than their extrinsic satisfaction. The results also showed that there was a significant relationship between teachers' motivation and job satisfaction dimensions, and the personal regulation and intrinsic motivation dimensions predicted the job satisfaction.