Significant research in science and mathematics education should advance the field's knowledge and understanding of the teaching and learning of science and mathematics. How, then, should the significance of a research question in science and mathematics education be assessed? And, when disseminating the findings of research, how should the significance of the research questions be communicated? In this study, we analyzed peer reviews to answer these questions. Our analysis revealed the main issues peer reviewers identify about research questions and the ways they are communicated during the dissemination of research. The findings provide insights for new and experienced researchers about communicating the significance of research questions, and they also illustrate how reviewer comments in peer-reviewed journals can provide a window into the field's frontiers.