The Strengths and Difficulties Questionnaire (SDQ) self-report form is a brief 25-item measure that assesses the psychological adjustment of youth. Although widely utilized as a screening tool, a lack of consistent psychometric evidence undermines the SDQ's utility as a sound diagnostic tool for all youth. This study focused on examining the psychometric evidence for the use of the SDQ with Latinx youth, the fastest-growing minority population in the United States and one of the most underserved. Three competing models were tested with a confirmatory factor approach in a sample of 771 sixth-grade English-speaking Latinx youth. Model fit was unsatisfactory in all three models, therefore an exploratory factor analysis (EFA) was conducted on an additional sample of Latinx youth, N = 422. EFA results suggested a two-factor model. Overall, results suggest that there is not yet adequate psychometric evidence for use of the SDQ self-report with Latinx youth. Future directions for research and implications for practice are highlighted.