The purpose of this study was to determine the effectiveness of teaching communicate with adolescents to their mothers and the methods of emotion regulation to adolescents on reducing stress and depression in adolescents of Eshkanan city. This study was a quasi-experimental research. The statistical population of this study consisted of students and their mothers. Sampling was performed by available sampling method and 40 mothers and 40 girls entered in study and replaced in two experimental (n = 20) and control (n =20) groups. The research instruments were adolescent depression (2000), the adolescent stress (2000), and questionnaires. The data was analyzed by descriptive and inferential statistics. The mean and standard deviation of the descriptive statistics, statistical analysis using SPSS and repeated measures analysis of inferential statistics were used to examine the hypotheses. The results showed that teaching communicate with adolescents to mothers and teaching the methods of emotion regulation to the adolescents were effective on reducing adolescents stress and depression during the time.