Social media are emerging technology which came into existence out of fun to connect with friends, but it has evolved to become a powerful tool for teaching and learning globally. However, despite its usefulness and relevance to learning the intention to use social media for learning by postgraduate gender in South-west Nigeria has not been confirmed. Therefore, the study used UTAUT model to established the intention to use social media for learning based on the interactive effect of postgraduate gender in South-west Nigeria. The study was a descriptive research of cross-sectional survey method and purposive sampling was used to sample 2,458 postgraduate students across the universities in South-west, Nigeria. Stratified sampling technique was used to select postgraduate students along gender and area of study. The questionnaire adapted was administered on 2,458 postgraduate students (1530 males and 928 females). Mean scores were used to answer research questions and t-test analysis was used to test research hypothesis. The findings of the study were that postgraduate students used Linkedin, Technorah, Blogger, Flickr, Myspace, Instagram, etc., postgraduate students had positive perception towards social media and intention to use for learning. The study concluded that postgraduate students' use social media for learning due to positive perception they had towards usefulness and ease of use of social media. It was however recommended that the use of social media should be encouraged in facilitating learning irrespective of students' gender and area of study.