In the United States, there is a growing sense of urgency and attention to the issues of equity and youth well-being. As a nation, we devote significant expertise and resources to addressing disparities and closing gaps among groups of young people, yet our progress has been slow, in no small part because our best efforts remain deeply fragmented. As a result, too many young people transition from adolescence to adulthood without the abilities, skillsets and mindsets they need to manage life's opportunities and challenges. The Readiness Project is designed to make science clear, accessible and actionable. It is a multi-year, multi-phase initiative that begins with comprehensive research to define readiness and the conditions and contexts that influence whether a young person is ready. It then moves to translate those findings into concrete tools and lessons that can be used by leaders, practitioners, policymakers, advocates and anyone else working to improve the lives of young people. This paper presents the findings of a three-year research effort to locate and synthesize the science of readiness. It is divided into two main sections: The first describes the overall science of readiness, the second dives more deeply into four core components of this science, offering examples of how organizations and communities can and are putting them to use.