Areas of critical health concerns for colleges and universities across the nation focus on substance abuse including alcohol and other drugs. Our State-Supported Regional University (SSRU) continues to implement a substance abuse prevention and awareness campaign. The SSRU administered the American College Health Association National College Health Assessment IIb (ACHA-NCHA IIb) (2015) to its undergraduate population. Healthy Campus 2020 topic areas measured are under Student Objectives and included Substance Abuse (SA), Health Communication (HC), and Education and Community Based Programs (ECBP). Two areas of health concern under Healthy Campus 2020 Student Objectives in the Substance Abuse area were identified where progress is critical. The results supported the SSRU's goals as it continues emphasizing substance abuse prevention through early education and prevention strategies coupled with continued support from the university's collaborative efforts among multiple university and community programs.