Introduction: Adolescence is a transition period between childhood and adulthood during which a decision to embark on a career is made. Furthermore, emotional intelligence is linked to self-efficacy in career decision-making, and some adolescents possess a proactive personality trait that seemingly strengthens the relation between the two concepts. Method: This study evaluated relations between emotional intelligence and career decision-making self-efficacy and considered whether such relations are moderated (strengthened or weakened) by proactive personality. A group sample (N = 840) from state senior high schools in Indonesia was surveyed. Results: Career decision-making self-efficacy correlated with emotional intelligence. Additionally, proactive personality had a moderating effect on the relation between emotional intelligence and career decision-making self-efficacy. Discussion and Conclusion: There is a significant positive relation exists between the two factors, and the hypothesis is accepted. The role of proactive personality suggests that career interventions should emphasize proactive personality aspects to increase the career decision-making self-efficacy of adolescents.