This article provides an overview of research in the Learning Sciences from a Design Research perspective, as it has been framed in Singapore by the National Institute of Education (NIE). The initial research agenda is considered in the light of challenges and the subsequent re-casting of objectives, based on the working out of a tripartite relationship between the NIE, the Ministry of Education, and local schools. A conceptual model is proposed as an attempt to provide structure for new research interventions going forward. (Contains 1 table.)