Teachers are highly concerned about students with Emotional and Behavioural Difficulties (EBD). Lately, much emphasis has been given to the field of prevention in schools, through the Competence-Enhancement Perspective. Emotional Intelligence (EI) and Social and Emotional Learning (SEL) provide the necessary skills to be acquired by students. The current study explored Greek in-service teachers' perceptions of the most important cognitive, emotional and social skills students should possess, in order to prevent the occurrence of EBD. It was found that teachers emphasised the importance of emotional skills. The study acknowledges teachers' significant role in children's social and emotional learning and advocates their involvement in the design of skills programmes for EBD pupils.