Social media now form a common part of university students' experience. Both at university and after graduation, in their personal and professional lives, social media offer opportunities for connection previously unavailable. The ubiquitous nature of social networking has brought with it professional and ethical issues that need to be addressed. Eprofessionalism, or professionalism in the digital media, has emerged as an important aspect of professional training across a range of disciplines. It is of particular importance in the field of health science due to the need to manage appropriate boundaries with clients. This article provides those involved in health science education with a brief introduction to eprofessionalism and social networking, a summary of the major research findings in this field, and a set of recommendations for initiating positive change in the university context.