This study explored the perceptions, attitudes, and willingness of pre-service science teachers in the College of Education at Kuwait University about using concept/mind maps and its related application software as facilitative tools, for teaching and learning, in science education. The first level (i.e., reaction) of Kirkpatrick's/Phillips' classic 5-level evaluation research model was exploited to assess and validate the reaction-based satisfaction level of pre-service science teachers. Although the findings disclose that 74.2 percent of participants asserted being aware about concept/mind maps beforehand. However, the vast majority, 96.8 percent, affirmed that they are not aware about concept/mind mapping application software. The results indicate that all participants were highly satisfied with utilizing concept/mind mapping and its related applications in education, accordingly, their reaction- based satisfaction level was extremely positive and significantly high among all subgroups. The participants favored utilizing such tools for constructing their concept/mind maps over hand-drawing or regular desktop productivity applications. Also, all participants do consider that concept/mind maps and its related application software as being appropriate, valuable, and useful facilitative and enhancement tools in education. They also do believe that these tools are important constituents for promoting thrive and success in science education.