As the world becomes increasingly interconnected, education systems must prepare students with the skills and knowledge to be able to thrive in a global economy and society. Toward this end, teachers play a key role in supporting students to develop as global citizens who bridge cultural divides, understand sustainable development issues, and act as changemakers in their communities. iEARN-USA connects an international community of K-12 educators and youth to collaborate and learn together on projects designed to make a difference in the world. Through iEARN programming, students can acquire important 21st-century skills and global competencies, allowing them to communicate ideas, recognize other perspectives, and take action while connecting their learning to real-world issues. This article describes iEARN-USA virtual projects; examples of ways youth are learning about global issues and making new friends, while developing global competencies through iEARN physical and interactive project exchanges; and initiatives and recognitions that demonstrate how iEARN continues to lead Global Education innovation.