New college and career ready standards (CCRS) have established more rigorous expectations of learning for all learners, including English learner (EL) students, than what was expected in previous standards. A common feature in these new content-area standards, such as the Common Core State Standards in English language arts and mathematics and the Next Generation Science Standards, is their emphasis on students' use of language to articulate and convey understanding of the content. The heightened role that language plays in CCRS presents new challenges for EL students and their teachers by calling for improved instructional strategies that simultaneously address language and content-area learning. The purpose of this resource is to provide teachers of EL students with effective, high-leverage learning and teaching principles that can be incorporated into daily instructional plans and routines. Instruction that addresses EL students' needs should include four key considerations: (1) Understand and address the academic language demands of the lesson; (2) Build upon students' background knowledge; (3) Design and scaffold learning opportunities in every lesson that integrate listening, speaking, reading, and writing domains; and (4) Provide opportunities for student participation through meaningful discourse and structured collaboration. The high-leverage principles for EL instruction presented in this resource are based on relevant research and most up-to-date literature on effective instruction. Each principle is accompanied by examples that illustrate its use. The resource concludes with an annotated classroom vignette that highlights the principles in action.