This study explored cultural and gender differences in career decision-making difficulties (CDMD) experienced by 109 British and 86 Chinese international university students, and the impact of cross-cultural adjustment on the CDMD of Chinese international students. Results showed no significant cultural differences in overall CDMD, and that the cross-cultural adjustment of Chinese participants was not correlated with their difficulty in career decision-making. Significant cultural differences on the sub-categories of the Career Decision-making Difficulties Questionnaire (e.g. Chinese participants were significantly less ready than British participants to make career decisions) and some significant gender differences (e.g. male participants generally experienced fewer difficulties than female participants in career decision-making) were identified. Age and degree level were negatively related to the level of difficulty the participants experienced in career decision-making. Implications for career counselling and future research directions are discussed. (Contains 6 tables.)