This study investigated questions adults asked to children with autism spectrum disorder in inclusive pre-kindergarten classrooms, and whether child (e.g. autism severity) and setting (i.e. adult-to-child ratio) characteristics were related to questions asked during center-time. Videos of verbal children with autism spectrum disorder (n?=?42) were coded based on the following question categories adapted from the work of Massey et al.: management, low cognitive challenging, or cognitively challenging. Results indicated that management questions (mean?=?19.97, standard deviation?=?12.71) were asked more than less cognitively challenging questions (mean?=?14.22, standard deviation?=?8.98) and less cognitively challenging questions were asked more than cognitively challenging questions (mean?=?10.00, standard deviation?=?6.9). Children with higher language levels had a greater likelihood of receiving cognitively challenging questions (odds ratio?=?1.025; p?=?0.007). Cognitively challenging questions had a greater likelihood of being asked in classrooms with more adults relative to children (odds ratio?=?1.176; p?=?0.037). The findings present a first step in identifying the questions directed at preschoolers with autism spectrum disorder in inclusive classrooms.