The longitudinal relationships between depression, anxiety, conduct problems, and inattention were investigated. The present study attempted to overcome the methodological limitations of prior research on childhood co-occurring syndromes by using continuous measures of constructs, controlling for multiple symptoms at baseline, and considering the role of age and gender. Using a community sample of 6-11 year-old children, we found evidence of homotypic and heterotypic continuity in baseline characteristics and their symptoms 5 years later. Notably, inattention and conduct problems were stable overtime regardless of age or gender. Additionally, inattention predicted subsequent depression, a relationship unaffected by overlapping psychopathology. With attention problems considered, conduct problems did not predict future depression as others have predicted. Instead, depression in young children was a unique risk factor for subsequent conduct problems. Similarly, most other relationships were moderated by age or gender. The implications for under-standing childhood psychopathology and for designing prevention and treatment programs are discussed. [This article was published in "Journal of Abnormal Child Psychology" (EJ811279).]