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Showing 31 to 45 of 1,241 results Save | Export
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Sanders, Erin M.; Nyarko-Odoom, Akua O.; Zhao, Kevin; Nguyen, Michael; Liao, Hong Hong Liao; Keith, Matthew; Pyon, Jane; Kozma, Alyssa; Sanyal, Mohima; McHail, Daniel G.; Dumas, Theodore C. – Learning & Memory, 2018
N-methyl-D-aspartate receptors (NMDARs) at excitatory synapses are central to activity-dependent synaptic plasticity and learning and memory. NMDARs act as ionotropic and metabotropic receptors by elevating postsynaptic calcium concentrations and by direct intracellular protein signaling. In the forebrain, these properties are controlled largely…
Descriptors: Learning, Long Term Memory, Statistical Analysis, Spatial Ability
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Yang, Qizong; Antonov, Igor; Castillejos, David; Nagaraj, Anagha; Bostwick, Caleb; Kohn, Andrea; Moroz, Leonid; Hawkins, Robert D. – Learning & Memory, 2018
Long-term but not short-term memory and synaptic plasticity in many brain areas require neurotrophin signaling, transcription, and epigenetic mechanisms including DNA methylation. However, it has been difficult to relate these cellular mechanisms directly to behavior because of the immense complexity of the mammalian brain. To address that…
Descriptors: Memory, Animals, Genetics, Brain
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Zhou, Wenxi; Chen, Haoyu; Yang, Jiongjiong – Learning & Memory, 2018
How to improve our episodic memory is an important issue in the field of memory. In the present study, we used a discriminative learning paradigm that was similar to a paradigm used in animal studies. In Experiment 1, a picture (e.g., a dog) was either paired with an identical picture, with a similar picture of the same concept (e.g., another…
Descriptors: Memory, Pictorial Stimuli, Eye Movements, Cognitive Processes
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Araiba, Sho; El Massioui, Nicole; Brown, Bruce L.; Doyère, Valérie – Learning & Memory, 2018
This study demonstrates that overtraining in temporal discrimination modifies temporal stimulus control in a bisection task and produces habitual responding, as evidenced through insensitivity to food devaluation. Rats were trained or overtrained in a 2-versus 8-sec temporal discrimination task, with each duration associated with a lever (left or…
Descriptors: Time, Training, Animals, Perception
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Cunningham, Tony J.; Leal, Stephanie L.; Yassa, Michael A.; Payne, Jessica D. – Learning & Memory, 2018
Stress influences how we remember emotional events and how these events shape future behaviors. However, the impact of stress on memory specificity for emotional events has yet to be examined. To this end, the present study utilized a mnemonic discrimination task that taxes hippocampal pattern separation, the process of distinguishing between…
Descriptors: Stress Variables, Brain Hemisphere Functions, Memory, Behavior Patterns
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Briggs, Sherri B.; Hafenbreidel, Madalyn; Young, Erica J.; Rumbaugh, Gavin; Miller, Courtney A. – Learning & Memory, 2018
Using pharmacologic and genetic approaches targeting actin or the actin-driving molecular motor, nonmuscle myosin II (NMII), we previously discovered an immediate, retrieval-independent, and long-lasting disruption of methamphetamine- (METH-) and amphetamine-associated memories. A single intrabasolateral amygdala complex infusion or systemic…
Descriptors: Role, Memory, Genetics, Drug Therapy
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Marshall, Andrew T.; Ostlund, Sean B. – Learning & Memory, 2018
Drug-paired cues acquire powerful motivational properties, but only lead to active drug-seeking behavior if they are potent enough to overwhelm the cognitive control processes that serve to suppress such urges. Studies using the Pavlovian-to-instrumental transfer (PIT) task have shown that rats pretreated with cocaine or amphetamine exhibit…
Descriptors: Cues, Drug Use, Animals, Delay of Gratification
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Peters, Jamie; Scofield, Michael D.; Reichel, Carmela M. – Learning & Memory, 2018
Prolonged use of methamphetamine (meth) has been associated with episodic memory deficits in humans, and preclinical rat models of meth self-administration indicate the memory deficits are a consequence of meth use. Others have suggested that the meth-induced memory deficits may promote a cyclical pattern of drug use, abstinence, and relapse,…
Descriptors: Drug Abuse, Memory, Brain Hemisphere Functions, Animals
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Gebhardt, Christine; Albrecht, Doris – Learning & Memory, 2018
Capsaicin has been shown to modulate synaptic plasticity in various brain regions including the amygdala. Whereas in the lateral amygdala the modulatory effect of capsaicin on long-term potentiation (LA-LTP) is mediated by TRPV1 channels, we have recently shown that capsaicin-induced enhancement of long term depression (LA-LTD) is mediated by…
Descriptors: Memory, Brain Hemisphere Functions, Depression (Psychology), Animals
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Foilb, Allison R.; Bals, Julia; Sarlitto, Mary C.; Christianson, John P. – Learning & Memory, 2018
Distinguishing safety from danger is necessary for survival, but is aberrant in individuals with post-traumatic stress disorder (PTSD). While PTSD is more prevalent in women than men, research on sex differences in safety learning is limited. Here, female rats demonstrated greater fear discrimination than males in a CS+/CS- paradigm. To determine…
Descriptors: Gender Differences, Posttraumatic Stress Disorder, Fear, Discrimination Learning
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Matell, Matthew S.; Della Valle, Rebecca B. – Learning & Memory, 2018
Presentation of a previously trained Pavlovian conditioned stimulus while an organism is engaged in operant responding can moderate the rate of responding, a phenomenon known as Pavlovian-to-instrumental transfer. Although it is well known that Pavlovian contingencies will generate conditioned behavior that is temporally organized with respect to…
Descriptors: Operant Conditioning, Experiments, Animals, Time
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Perez, Leticia; Patel, Ushma; Rivota, Marissa; Calin-Jageman, Irina E.; Calin-Jageman, Robert J. – Learning & Memory, 2018
Most long-term memories are forgotten. What happens, then, to the changes in neuronal gene expression that were initially required to encode and maintain the memory? Here we show that the decay of recall for long-term sensitization memory in "Aplysia" is accompanied both by a form of savings memory (easier relearning) and by persistent…
Descriptors: Long Term Memory, Genetics, Recall (Psychology), Animals
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Vogel, Susanne; Kluen, Lisa Marieke; Fernández, Guillén; Schwabe, Lars – Learning & Memory, 2018
Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus, however, is crucial for encoding…
Descriptors: Stress Variables, Brain Hemisphere Functions, Cognitive Processes, Schemata (Cognition)
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Newsome, Rachel N.; Trelle, Alexandra N.; Fidalgo, Celia; Hong, Bryan; Smith, Victoria M.; Jacob, Alexander; Ryan, Jennifer D.; Rosenbaum, R. Shayna; Cowell, Rosemary A.; Barense, Morgan D. – Learning & Memory, 2018
The thalamic nuclei are thought to play a critical role in recognition memory. Specifically, the anterior thalamic nuclei and medial dorsal nuclei may serve as critical output structures in distinct hippocampal and perirhinal cortex systems, respectively. Existing evidence indicates that damage to the anterior thalamic nuclei leads to impairments…
Descriptors: Memory, Recognition (Psychology), Brain Hemisphere Functions, Neurological Impairments
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Briskin-Luchinsky, Valeria; Levy, Roi; Halfon, Maayan; Susswein, Abraham J. – Learning & Memory, 2018
Training "Aplysia" with inedible food for a period that is too brief to produce long-term memory becomes effective in producing memory when training is paired with a nitric oxide (NO) donor. Lip stimulation for the same period of time paired with an NO donor is ineffective. Using qPCR, we examined molecular correlates of brief training…
Descriptors: Animals, Training, Food, Long Term Memory
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