ERIC Number: EJ1206331
Record Type: Journal
Publication Date: 2019-Mar
Abstractor: As Provided
Spatial Memory Formation Requires Netrin-1 Expression by Neurons in the Adult Mammalian Brain
Wong, Edwin W.; Glasgow, Stephen D.; Trigiani, Lianne J.; Chitsaz, Daryan; Rymar, Vladimir; Sadikot, Abbas; Ruthazer, Edward S.; Hamel, Edith; Kennedy, Timothy E.
Learning & Memory, v26 n3 p77-83 Mar 2019
Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the postnatal and adult mammalian brain. Netrin-1 and the netrin receptor DCC are both enriched at synapses. In the adult hippocampus, activity-dependent secretion of netrin-1 by neurons potentiates glutamatergic synapse function, and is critical for long-term potentiation, an experimental cellular model of learning and memory. Here, we assessed the impact of neuronal expression of netrin-1 in the adult brain on behavior using tests of learning and memory. We show that adult mice exhibit impaired spatial memory following conditional deletion of netrin-1 from glutamatergic neurons in the hippocampus and neocortex. Further, we provide evidence that mice with conditional deletion of netrin-1 do not display aberrant anxiety-like phenotypes and show a reduction in self-grooming behavior. These findings reveal a critical role for netrin-1 expressed by neurons in the regulation of spatial memory formation.
Descriptors: Spatial Ability, Memory, Adults, Brain, Foreign Countries, Animals, Brain Hemisphere Functions, Cues, Neurology
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Location: Canada (Montreal)