In this article, the authors describe the use of curriculum-based measurement (CBM) reading measures within a response-to-intervention (RTI) framework. They examine the characteristics of the measures to illustrate their technical adequacy for use at each tier in an RTI model. Finally, they look at the use of the measures at Tier 3 (special education services) with respect to informing instruction and satisfying the legal requirements of the Individuals with Disabilities Education Improvement Act of 2004. (Contains 6 figures.)