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Showing 1 to 15 of 73 results Save | Export
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Zyga, Olena; Dimitropoulos, Anastasia – American Journal on Intellectual and Developmental Disabilities, 2020
Early parent-child interactions (PCI) impact social cognitive development. Relatedly, children with various developmental disorders exhibit abnormal parental attachment relationships. Parental characteristics and behaviors can impact PCI and socioemotional development as well. No research has examined the parent-child dynamic in Prader-Willi…
Descriptors: Preschool Children, Parent Child Relationship, Genetic Disorders, Stress Variables
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Capone, George T. – American Journal on Intellectual and Developmental Disabilities, 2020
Translational research means different things to different people. In the biomedical research community, translational research is the process of applying knowledge from basic biology and clinical trials to techniques and tools that address critical medical needs such as new therapies. Translational research then is a "bench to bedside"…
Descriptors: Down Syndrome, Research, Genetic Disorders, Physiology
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Haydar, Tarik F. – American Journal on Intellectual and Developmental Disabilities, 2020
One of the overriding hopes of the Down syndrome (DS) research community is to arrive at a better understanding of how trisomy 21 affects brain development and function, and that doing so will improve quality of life and independence for people with DS. In searching for the underlying causes of intellectual disability in DS, researchers and…
Descriptors: Down Syndrome, Medical Research, Brain Hemisphere Functions, Genetic Disorders
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Handen, Benjamin L. – American Journal on Intellectual and Developmental Disabilities, 2020
Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid…
Descriptors: Adults, Down Syndrome, Alzheimers Disease, At Risk Persons
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Do, Thuy Quynh N.; Riley, Catharine; Paramsothy, Pangaja; Ouyang, Lijing; Bolen, Julie; Grosse, Scott D. – American Journal on Intellectual and Developmental Disabilities, 2020
Using national data, we examined emergency department (ED) encounters during 2006-2011 for which a diagnosis code for fragile X syndrome (FXS) was present (n = 7,217). Almost half of ED visits coded for FXS resulted in hospitalization, which is much higher than for ED visits not coded for FXS. ED visits among females coded for FXS were slightly…
Descriptors: Hospitals, Genetic Disorders, Gender Differences, At Risk Persons
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Britton, Tobias C.; Wilkinson, Ellen H.; Hall, Scott S. – American Journal on Intellectual and Developmental Disabilities, 2020
Limited information is available concerning the specificity of the forms and functions of aggressive behavior exhibited by boys with fragile X syndrome (FXS). To investigate these relationships, we conducted indirect functional assessments of aggressive behavior exhibited by 41 adolescent boys with FXS and 59 age and symptom-matched controls with…
Descriptors: Aggression, Males, Genetic Disorders, Adolescents
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Nash, Rebecca; Riley, Catharine; Paramsothy, Pangaja; Gilbertson, Kendra; Raspa, Melissa; Wheeler, Anne; Dziuban, Eric J.; Peacock, Georgina – American Journal on Intellectual and Developmental Disabilities, 2019
Children with fragile X syndrome (FXS) display wide-ranging intellectual and behavioral abilities that affect daily life. We describe the educational setting of students with FXS and assess the relationships between school setting, co-occurring conditions, and functional ability using a national survey sample (n = 982). The majority of students…
Descriptors: Genetic Disorders, Intellectual Disability, Behavior Problems, Individualized Education Programs
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Joyce, Anna; Hill, Catherine M.; Karmiloff-Smith, Annette; Dimitriou, Dagmara – American Journal on Intellectual and Developmental Disabilities, 2019
Sleep plays a key role in the consolidation of newly acquired information and skills into long term memory. Children with Down syndrome (DS) and Williams syndrome (WS) frequently experience sleep problems, abnormal sleep architecture, and difficulties with learning; thus, we predicted that children from these clinical populations would demonstrate…
Descriptors: Sleep, Cognitive Processes, Down Syndrome, Genetic Disorders
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Hamrick, Lisa R.; Tonnsen, Bridgette L. – American Journal on Intellectual and Developmental Disabilities, 2019
Although social communication skills are commonly delayed in children with neurogenetic syndromes (NGS), skill profiles in very young children are largely under characterized, in part due to the lack of validated assessment measures appropriate for these populations. We addressed this gap by validating and applying a popular early social…
Descriptors: Rating Scales, Genetic Disorders, Test Validity, Interpersonal Communication
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Adams, Dawn; Clarke, Samantha; Griffith, Gemma; Howlin, Pat; Moss, Jo; Petty, Jane; Tunnicliffe, Penny; Oliver, Chris – American Journal on Intellectual and Developmental Disabilities, 2018
It is well documented that mothers of children with challenging behavior (CB) experience elevated levels of stress and that this persists over time, but less is known about the experience of mothers of children with rare genetic syndromes. This article describes 2 studies, 1 cross-sectional and 1 longitudinal, comparing well-being in mothers of…
Descriptors: Mothers, Stress Variables, Genetic Disorders, Depression (Psychology)
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Adlof, Suzanne M.; Klusek, Jessica; Hoffmann, Anne; Chitwood, Kerrie L.; Brazendale, Allison; Riley, Karen; Abbeduto, Leonard J.; Roberts, Jane E. – American Journal on Intellectual and Developmental Disabilities, 2018
Individuals with fragile X syndrome (FXS) present with significant deficits in reading skills, but scant research exists to understand the characteristics of the reading delays or best practices for reading instruction with this population. Study 1 examined the relationship between phonological awareness and reading skills in individuals with FXS.…
Descriptors: Child Rearing, Genetic Disorders, Reading Difficulties, Teaching Methods
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Hodnett, Jennifer; Scheithauer, Mindy; Call, Nathan A.; Mevers, Joanne Lomas; Miller, Sarah J. – American Journal on Intellectual and Developmental Disabilities, 2018
Smith-Magenis syndrome (SMS) is a genetic disorder, commonly caused by a 17p11.2 deletion, affecting the Retinoic Acid Induced 1 gene. It affects approximately 1 in 25,000 individuals, with over 90% engaging in challenging behaviors. Function-based treatments, using the principles of applied behavior analysis, have consistently been shown to…
Descriptors: Functional Behavioral Assessment, Behavior Problems, Genetic Disorders, Developmental Delays
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Zyga, Olena; Russ, Sandra W.; Dimitropoulos, Anastasia – American Journal on Intellectual and Developmental Disabilities, 2018
Research has shown that children with Prader-Willi syndrome (PWS) have social-cognitive challenges and decreased quality parent-child interactions. However, given the low prevalence rate, developing interventions for children with PWS is faced with the significant challenge of enrolling enough participants for local studies. To better understand…
Descriptors: Genetic Disorders, Intellectual Disability, Interpersonal Competence, Parent Child Relationship
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Robinson, Marissa; Klusek, Jessica; Poe, Michele D.; Hatton, Deborah D.; Roberts, Jane E. – American Journal on Intellectual and Developmental Disabilities, 2018
Effortful control, or the ability to suppress a dominant response to perform a subdominant response, is an early-emerging temperament trait that is linked with positive social-emotional development. Fragile X syndrome (FXS) is a single-gene disorder characterized by hallmark regulatory impairments, suggesting diminished effortful control. This…
Descriptors: Genetic Disorders, Congenital Impairments, Intellectual Disability, Males
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Pérez-García, Débora; Brun-Gasca, Carme; Pérez-Jurado, Luis A.; Mervis, Carolyn B. – American Journal on Intellectual and Developmental Disabilities, 2017
To identify similarities and differences in the behavioral profile of children with Williams syndrome from Spain (n = 53) and the United States (n = 145), we asked parents of 6- to 14-year-olds with Williams syndrome to complete the Child Behavior Checklist 6-18. The distribution of raw scores was significantly higher for the Spanish sample than…
Descriptors: Foreign Countries, Child Behavior, Genetic Disorders, Children
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