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Bhattacharyya, Anita – American Journal on Intellectual and Developmental Disabilities, 2020
Our bodies are made up of over 250 specific cell types, and all initially arise from stem cells during embryonic development. Stem cells have two characteristics that make them unique: (1) they are pluripotent, meaning that they can differentiate into all cell types of the body, and (2) they are capable of self-renewal to generate more of…
Descriptors: Down Syndrome, Brain, Individual Development, Intellectual Disability
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Capone, George T. – American Journal on Intellectual and Developmental Disabilities, 2020
Translational research means different things to different people. In the biomedical research community, translational research is the process of applying knowledge from basic biology and clinical trials to techniques and tools that address critical medical needs such as new therapies. Translational research then is a "bench to bedside"…
Descriptors: Down Syndrome, Research, Genetic Disorders, Physiology
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Handen, Benjamin L. – American Journal on Intellectual and Developmental Disabilities, 2020
Adults with Down syndrome are at high risk for Alzheimer's disease (AD), with most individuals developing clinical dementia by their late 60s. This increased risk for AD has been attributed, at least in part, to triplication and overexpression of the gene for amyloid precursor protein (APP) on chromosome 21, leading to elevated levels of amyloid…
Descriptors: Adults, Down Syndrome, Alzheimers Disease, At Risk Persons
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Ledford, Jennifer R.; Barton, Erin E.; Severini, Katherine E.; Zimmerman, Kathleen N. – American Journal on Intellectual and Developmental Disabilities, 2019
The overarching purpose of this article is to provide an introduction to the use of rigorous single-case research designs (SCRDs) in special education and related fields. Authors first discuss basic design types and research questions that can be answered with SCRDs, examine threats to internal validity and potential ways to control for and detect…
Descriptors: Special Education, Research Methodology, Case Studies, Research Design
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Reinders, Hans S.; Schalock, Robert L. – American Journal on Intellectual and Developmental Disabilities, 2014
This article presents the framework of a dynamic approach to quality of life (QOL) enhancement based on the conceptualization and measurement of individual-referenced quality of life. Sections of the article summarize the premises of QOL enhancement, provide the rationale for a dynamic approach to QOL enhancement, discuss six components of QOL…
Descriptors: Quality of Life, Disabilities, Individual Needs, Individual Characteristics
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Tasse, Marc J.; Schalock, Robert L.; Balboni, Giulia; Bersani, Hank, Jr.; Borthwick-Duffy, Sharon A.; Spreat, Scott; Thissen, David; Widaman, Keith F.; Zhang, Dalun – American Journal on Intellectual and Developmental Disabilities, 2012
This article updates the current conceptualization, measurement, and use of the adaptive behavior construct. Major sections of the article address an understanding of the construct, the current approaches to its measurement, four assessment issues and challenges related to the use of adaptive behavior information for the diagnosis of intellectual…
Descriptors: Adjustment (to Environment), Mental Retardation, Measurement, Evaluation
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Fesko, Sheila Lynch; Hall, Allison Cohen; Quinlan, Jerrilyn; Jockell, Catherine – American Journal on Intellectual and Developmental Disabilities, 2012
As individuals with intellectual and developmental disabilities become more engaged in community employment, it will be critical to consider how their employment experience changes as they age. Similar to other seniors, individuals will need to consider whether they want to maintain their employment, reduce their work commitment, or retire…
Descriptors: Retirement, Developmental Disabilities, Mental Retardation, Employment Level
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Courtemanche, Andrea B.; Schroeder, Stephen R.; Sheldon, Jan B. – American Journal on Intellectual and Developmental Disabilities, 2011
A combination of behavioral and medication-based interventions has been the most effective form of treatment for reducing problem behavior in individuals with intellectual and developmental disabilities. Evaluating the 2 types of interventions in combination and separately may require that researchers adapt methods traditionally used to evaluate…
Descriptors: Control Groups, Mental Retardation, Developmental Disabilities, Methods
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Couzens, Donna; Cuskelly, Monica; Haynes, Michele – American Journal on Intellectual and Developmental Disabilities, 2011
Growth models for subtests of the Stanford-Binet Intelligence Scale, 4th edition (R. L. Thorndike, E. P. Hagen, & J. M. Sattler, 1986a, 1986b) were developed for individuals with Down syndrome. Models were based on the assessments of 208 individuals who participated in longitudinal and cross-sectional research between 1987 and 2004. Variation…
Descriptors: Sentences, Down Syndrome, Memory, Cognitive Development
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Fisher, Kathleen M.; Orkin, Fredrick K.; Green, Michael J.; Chinchilli, Vernon M.; Bhattacharya, Anand – American Journal on Intellectual and Developmental Disabilities, 2009
Directors of residential agencies for persons with intellectual disability in one U.S. state completed a self-administered, mailed survey to assess relative importance of information sources and decision factors in proxy healthcare decision-making. The most important sources were physician recommendations and input from the person; family input,…
Descriptors: Mental Retardation, Health Conditions, Interests, Information Sources