This study investigated children's interest-based activities in the home during the preschool years and their subsequent academic self-regulation behaviors in school. Children's home activities were tracked for 1 year prior to kindergarten entry. Based on their profiles of activities, children (109) were assigned to one of four interest groups: conceptual, social, procedural, or creative. The children's academic self-regulation behaviors were observed throughout kindergarten. Specifically, the contribution of children's early interests to understanding their metacognitive talk and progress monitoring was analyzed, controlling statistically for the effects of gender, cognitive skill, and temperament. There were discernible patterns unique to each group in the content of their metacognitive talk and strategies for monitoring progress. The study offers an uncommonly rich description of the academic self-regulation behaviors of young children and explores the role of early childhood interests in the development of academic self-regulation.