Universal Design for Instruction (UDI) is a set of principles helpful in guiding the process of designing classroom environments and instruction that are conducive to the learning of all students. UDI, designed by the Center for Applied Special Technology, is a framework that has been successful for all students, including those with disabilities in general education settings. UDI ensures that all students have access to instruction through the following principles: (1) equitable use; (2) flexibility in use; (3) simple and intuitive; (4) perceptible information; (5) tolerance for error; (6) low physical effort; and (7) size and space for approach and use. In this article, the author provides an overview of UDI, as well as practical classroom applications for elementary and middle school teachers. (Contains 2 tables and 2 figures.)