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Mbwana, J.; Berl, M. M.; Ritzl, E. K.; Rosenberger, L.; Mayo, J.; Weinstein, S.; Conry, J. A.; Pearl, P. L.; Shamim, S.; Moore, E. N.; Sato, S.; Vezina, L. G.; Theodore, W. H.; Gaillard, W. D. – Brain, 2009
Neural networks for processing language often are reorganized in patients with epilepsy. However, the extent and location of within and between hemisphere re-organization are not established. We studied 45 patients, all with a left hemisphere seizure focus (mean age 22.8, seizure onset 13.3), and 19 normal controls (mean age 24.8) with an fMRI…
Descriptors: Brain Hemisphere Functions, Epilepsy, Patients, Language Processing
Parkinson's Disease and Dopaminergic Therapy--Differential Effects on Movement, Reward and Cognition
Rowe, J. B.; Hughes, L.; Ghosh, B. C. P.; Eckstein, D.; Williams-Gray, C. H.; Fallon, S.; Barker, R. A.; Owen, A. M. – Brain, 2008
Cognitive deficits are very common in Parkinson's disease particularly for "executive functions" associated with frontal cortico-striatal networks. Previous work has identified deficits in tasks that require attentional control like task-switching, and reward-based tasks like gambling or reversal learning. However, there is a complex…
Descriptors: Diseases, Patients, Rewards, Drug Therapy
fMRI Correlates of State and Trait Effects in Subjects at Genetically Enhanced Risk of Schizophrenia
Whalley, Heather C.; Simonotto, E.; Flett, S.; Marshal, I.; Ebmeier, K. P.; Owens, D. G. C.; Goddard, N. H.; Johnstone, E. C.; Lawrie, S. M. – Brain, 2004
Schizophrenia is a highly heritable disorder that typically develops in early adult life. Structural imaging studies have indicated that patients with the illness, and to some extent their unaffected relatives, have subtle deficits in several brain regions, including prefrontal and temporal lobes. It is, however, not known how this inherited…
Descriptors: Schizophrenia, Genetics, Correlation, Heredity